Physiologically Responsive Polyurethanes for Tissue Repair and Regeneration

Polyurethanes have been broadly used as biomaterials in tissue repair and regeneration due to their preeminent biocompatibility mechanical properties. However, traditional polyurethanes are not able efficiently cope with the complexity of dynamic microenvironments during process disease therapy. Physiologically responsive responding or reacting biological signals pathological abnormalities can change physicochemical properties, enabling on-demand release intelligently promoting regeneration. So far, physiologically gained significant interest for applications controlled drug delivery systems engineering recent years. This review highlights research advances design physiological-responsive regeneration, particular attention some representative examples such pH-, redox-, temperature-, enzyme-responsive polyurethanes. The key principles illustrated treatment retinal detachment, gastric ulcer, wound, myocardial infarction, lung injury, bone defect, osteoarthritis. challenges future perspectives finally discussed.